Dietrich A, Mortensen M E, Wheller J
Division of Emergency Medicine, Ohio State University, Columbus.
J Adolesc Health. 1993 Jul;14(5):394-7. doi: 10.1016/s1054-139x(08)80014-6.
A case report is presented of an adolescent male who developed hypothyroidism and cardiomyopathy 6 months after he began taking lithium and imipramine for a severe conduct disorder. After discontinuation of psychiatric medications and institution of thyroid hormone replacement therapy, he developed asymptomatic but potentially serious dysrhythmias. Evidence for potential cardiac toxicity of combined lithium and tricyclic antidepressant therapy is reviewed. Repeated assessment of cardiac function during such therapy is advised.
本文报告了一例青少年男性病例，该患者在开始服用锂盐和丙咪嗪治疗严重品行障碍6个月后出现甲状腺功能减退和心肌病。在停用精神科药物并开始甲状腺激素替代治疗后，他出现了无症状但可能严重的心律失常。本文回顾了锂盐和三环类抗抑郁药联合治疗可能导致心脏毒性的证据。建议在这种治疗期间反复评估心脏功能。
