Gwathmey J K, Davidoff A J
Cardiovascular Disease and Muscle Research Laboratories, Harvard Medical School, Boston, Massachusetts.
Curr Opin Cardiol. 1994 May;9(3):369-78.
Drug-induced cardiomyopathies are becoming widely used as models of heart failure. These models offer the advantage of precise control of the onset time and can often be studied in a longitudinal fashion. Toxin- and tachycardia-induced models, as well as nutritional deficiency models, possess certain clinically relevant features, thereby enhancing their appeal. By studying these types of models, key components of heart disease can be elucidated, and may provide important new insights into the pathophysiology of the clinical and functional end-point: heart failure.
药物性心肌病正被广泛用作心力衰竭的模型。这些模型具有 onset 时间精确可控的优势，并且通常可以纵向研究。毒素和心动过速诱导的模型以及营养缺乏模型具有某些临床相关特征，从而增强了它们的吸引力。通过研究这些类型的模型，可以阐明心脏病的关键组成部分，并可能为临床和功能终点——心力衰竭的病理生理学提供重要的新见解。
