Federico A
Riv Neurol. 1975 Oct-Dec;45(4):418-38.
This is a synthetic report about multiple sclerosis: there is described the neuropathology (by optic and electronic microscopy) of this disease, the changes in the protein metabolism, above all in basic protein content, in lipids, in enzymes of the plaques and of the apparently normal white and gray matter. There are afterwords described the relationship between viruses and multiple sclerosis, the probable action mechanism of the virus-determined demyelination, and the changes of the immunitary system (increase of gamma-globulins, serum myelotoxicity, lymphocitary changes).
文中描述了该疾病的神经病理学（通过光学和电子显微镜观察）、蛋白质代谢的变化，尤其是碱性蛋白含量、脂质、斑块以及明显正常的白质和灰质中酶的变化。随后还描述了病毒与多发性硬化症之间的关系、病毒引发脱髓鞘的可能作用机制以及免疫系统的变化（γ-球蛋白增加、血清髓毒性、淋巴细胞变化）。
