Libický A, Kubánková V, Fidlerová J, Pipota J
Institut pro dalsí vzdĕlávání lékarů a farmaceutů, Praha.
Cesk Farm. 1993 Apr;42(2):77-81.
The present paper examined the effect of ionizing radiation (source, 60Co) within a range of doses from 10 to 120 kGy on amylolytic efficacy of pancreatin of two types: pancreatin obtained by isolation from an extract of the pancreas (sample 1) and pancreatin containing parts of the pancreatic tissue, but with higher amylolytic efficacy (sample 2). Efficacy was expressed in F.I.P. units. As shown in the chart, a percentual decrease in efficacy is higher in the more active sample 2. Graphical representation is in good agreement with the statistical evaluation of the significance between the decreases in efficacy in both samples irradiated with doses of 30 and 120 kGy, if the median test was used and probability was calculated with the use of Fisher's test. This is not, however, the case of irradiation with a dose of 10 kGy. The residual, graphically corrected efficacy after irradiation with a sterilizing dose of 25 kGy was 84.1% (sample 1) and 80.3% (sample 2). With the maximal dose used, the residual efficacy was 43.7% (sample 1) and 36.7% (sample 2).
本文研究了剂量范围为10至120千戈瑞的电离辐射（源为60Co）对两种胰酶淀粉酶解效力的影响：一种是从胰腺提取物中分离得到的胰酶（样品1），另一种是含有部分胰腺组织但淀粉酶解效力更高的胰酶（样品2）。效力以国际药学联合会（F.I.P.）单位表示。如图表所示，活性更高的样品2中效力的百分比下降幅度更大。如果使用中位数检验并通过费舍尔检验计算概率，图形表示与对30和120千戈瑞剂量照射的两个样品效力下降之间的显著性统计评估结果高度一致。然而，10千戈瑞剂量照射的情况并非如此。用25千戈瑞灭菌剂量照射后的残留图形校正效力，样品1为84.1%，样品2为8... 展开 0.3%。使用最大剂量时，残留效力样品1为43.7%，样品2为36.7%。
