Koh K T, Chia K S, Tan C
Department of Community Occupational & Family Medicine, National University Hospital, Singapore.
Diabetes Res Clin Pract. 1993 Jun;20(3):215-21. doi: 10.1016/0168-8227(93)90081-f.
Urine albumin, alpha 1- and beta 2-microglobulins, retinol-binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG) were measured in early morning urine samples from 99 non-insulin-dependent diabetic (NIDDM) patients receiving ambulatory care at a primary health care polyclinic. Elevated NAG levels were found in 90% of diabetics regardless of the duration of their disease. Almost half (43.4%) of the subjects had microalbuminuria. Over a third of the subjects without albuminuria had elevated alpha 1-microglobulin levels in their urine. The proportion of subjects with elevated alpha 1 levels increased significantly with the presence of albumin, poor glycaemic control and increased duration of disease. These findings suggest that proximal tubular as well glomerular dysfunction coexist in the NIDDM patients studied.
对在一家初级卫生保健综合诊所接受门诊治疗的99例非胰岛素依赖型糖尿病（NIDDM）患者的晨尿样本进行了尿白蛋白、α1和β2微球蛋白、视黄醇结合蛋白（RBP）以及N-乙酰-β-D-氨基葡萄糖苷酶（NAG）检测。90%的糖尿病患者NAG水平升高，无论其病程长短。近一半（43.4%）的受试者存在微量白蛋白尿。超过三分之一无白蛋白尿的受试者尿中α1微球蛋白水平升高。α1水平升高的受试者比例随着白蛋白的存在、血糖控制不佳以及病程延长而显著增加。这些发现表明，在所研究的NIDDM患者中，近端肾小管和肾小球功能障碍并存。
