人腱生蛋白不同表位特异性单克隆抗体的制备与特性分析
Production and characterization of monoclonal antibodies specific for different epitopes of human tenascin.
作者信息
Balza E, Siri A, Ponassi M, Caocci F, Linnala A, Virtanen I, Zardi L
机构信息
Laboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
出版信息
FEBS Lett. 1993 Oct 11;332(1-2):39-43. doi: 10.1016/0014-5793(93)80479-e.
We have obtained and characterized 11 monoclonal antibodies (mAbs) specific for different domains of human tenascin (TN). Five of these mAbs reacted with epitopes contained in the TN area that undergoes alternative splicing and are thus able to recognize specific TN isoforms. These mAbs are a useful tool to study the expression and distribution of TN and its different isoforms in normal and pathological tissues.
我们已经获得并鉴定了11种针对人腱生蛋白（TN）不同结构域的单克隆抗体（mAb）。其中5种mAb与TN区域中发生可变剪接的表位发生反应，因此能够识别特定的TN异构体。这些mAb是研究TN及其不同异构体在正常和病理组织中的表达和分布的有用工具。
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