Singh P, Rubin N
Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston.
Gastroenterology. 1993 Oct;105(4):1218-37. doi: 10.1016/0016-5085(93)90971-e.
Insulinlike growth factors (IGFs) express anabolic and mitogenic activity on wide variety of cells. Besides endocrine effects, IGFs have major autocrine and paracrine effects on many cellular functions. Two factors that significantly affect the extent of cellular response to IGFs include the membrane receptors for IGFs and the soluble binding proteins (BPs), which modulate the action of IGFs at the receptor level. IGFs, IGF receptors, and IGFs and their BPs (IGF-BPs) thus constitute three components of the IGF system. A role of IGFs in the transformation and proliferation of cancer cells has become increasingly evident in the past few years. Studies from several laboratories show that all three components of the IGF system may play an important role in the proliferation of colon cancers. It was recently shown that the relative expression of IGFs and IGF/BPs may critically control the metastatic potential of colon cancers. The purpose of this article is to summarize our current knowledge of the IGF system and to present support for a significant role of IGFs in the initiation and growth of colon cancers. The expression and structural aspects of IGFs, their receptors, and BPs are outlined first, followed by a discussion of the role of IGFs in gastrointestinal functions and in colon cancers.
胰岛素样生长因子（IGFs）对多种细胞具有合成代谢和促有丝分裂活性。除内分泌作用外，IGFs对许多细胞功能还具有主要的自分泌和旁分泌作用。显著影响细胞对IGFs反应程度的两个因素包括IGFs的膜受体和可溶性结合蛋白（BPs），它们在受体水平调节IGFs的作用。因此，IGFs、IGF受体以及IGFs及其BPs（IGF-BPs）构成了IGF系统的三个组成部分。在过去几年中，IGFs在癌细胞的转化和增殖中的作用日益明显。几个实验室的研究表明，IGF系统的所有三个组成部分可能在结肠癌的增殖中发挥重要作用。最近有研究表明，IGFs和IGF/BPs的相对表达可能对结肠癌的转移潜能起关键控制作用。本文的目的是总结我们目前对IGF系统的认识，并为IGFs在结肠癌的发生和发展中起重要作用提供依据。首先概述IGFs、其受体和BPs的表达及结构方面，随后讨论IGFs在胃肠功能和结肠癌中的作用。
