The Rockefeller University, New York, NY, USA.
Department of Medical and Surgical Sciences, University of Bologna, Italy.
Gastroenterology. 2014 Feb;146(2):357-373. doi: 10.1053/j.gastro.2013.11.051. Epub 2013 Dec 6.
Obesity is among the fastest growing diseases worldwide; treatment is inadequate, and associated disorders, including gastrointestinal cancers, have high morbidity and mortality. An increased understanding of the mechanisms of obesity-induced carcinogenesis is required to develop methods to prevent or treat these cancers. In this report, we review the mechanisms of obesity-associated colorectal, esophageal, gastric, and pancreatic cancers and potential treatment strategies.
肥胖症是全球增长最快的疾病之一；治疗效果不佳，且相关疾病（包括胃肠道癌症）的发病率和死亡率都很高。为了开发预防或治疗这些癌症的方法，需要深入了解肥胖引起的致癌机制。在本报告中，我们综述了肥胖相关的结直肠癌、食管癌、胃癌和胰腺癌的发生机制以及潜在的治疗策略。
