Slovak M L, Weiss L M, Nathwani B N, Bernstein L, Levine A M
Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA 91010-0269.
Hum Pathol. 1993 Oct;24(10):1086-94. doi: 10.1016/0046-8177(93)90188-m.
Monocytoid B-cell lymphoma (MBCL) is a newly recognized, morphologically and immunologically distinct, low-grade B-cell neoplasm that may exist as a pure morphologic entity or as a component of a composite lymphoma. To determine whether cytogenetic abnormalities exist in cases of MBCL, fresh tissue from four lymphoma specimens in which MBCL was a substantial component were analyzed by classic cytogenetics; no pure MBCL cases were available for study. One monoclonal neoplastic population was found in each case by immunophenotyping studies and classic cytogenetics. Clonal cytogenetic abnormalities included -X or +X, t(14;18)(q32;q21), del(6q), t(11;14)(q13;q32), dup(12q), dup(1q), t(2;3)(q13;q29), and der(8)t(8;9)(p11.2;q13). The abnormal clone usually reflected the underlying lymphomatous process, namely, follicular lymphoma [t(14;18)], mantle cell lymphoma [t(11;14)], or small lymphocytic lymphoma (partial trisomy 12). There were no cytogenetic abnormalities common to all neoplasms. Taken together, the cytogenetic and immunologic data suggest that although MBCL may exist as a pure entity, it also may commonly represent a morphologic variant or a component of other primary lymphomatous processes.
单核细胞样B细胞淋巴瘤（MBCL）是一种新认识的、形态学和免疫学上均有独特表现的低度B细胞肿瘤，它可以作为一种单纯的形态学实体存在，也可以作为复合淋巴瘤的一个组成部分。为了确定MBCL病例中是否存在细胞遗传学异常，我们采用经典细胞遗传学方法分析了4例以MBCL为主要成分的淋巴瘤标本的新鲜组织；没有单纯的MBCL病例可供研究。通过免疫表型研究和经典细胞遗传学方法，在每个病例中均发现了一个单克隆肿瘤细胞群。克隆性细胞遗传学异常包括-X或+X、t(14;18)(q32;q21)、del(6q)、t(11;14)(q13;q32)、dup(12q)、dup(1q)、t(2;3)(q13;q29)以及der(8)t(8;9)(p11.2;q13)。异常克隆通常反映了潜在的淋巴瘤过程，即滤泡性淋巴瘤[t(14;18)]、套细胞淋巴瘤[t(11;14)]或小淋巴细胞淋巴瘤（12号染色体部分三体）。所有肿瘤中没有共同的细胞遗传学异常。综合细胞遗传学和免疫学数据表明，尽管MBCL可能作为一种单纯的实体存在，但它也可能通常代表其他原发性淋巴瘤过程的一种形态学变异或组成部分。
