McCarron R M, Wang L, Stanimirovic D B, Spatz M
Stroke Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892.
Neurosci Lett. 1993 Jun 25;156(1-2):31-4. doi: 10.1016/0304-3940(93)90432-k.
The adhesion of circulating leukocytes to vascular endothelium is a prerequisite for their emigration to extravascular tissues. The experiments presented here demonstrate that intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are constitutively expressed on cerebromicrovascular endothelial cell lines derived from human brain and that the expression of these molecules can be up-regulated by endothelins (ET-1, ET-2, and ET-3) in a dose- and time-dependent manner. The data also indicate that ET-1 treatment induced the expression of E-selectin on these cells. These findings implicate vasoactive peptides in the recruitment of blood cells at sites of inflammation.
循环白细胞与血管内皮的黏附是其迁移至血管外组织的前提条件。本文所展示的实验表明，细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子-1（VCAM-1）在源自人脑的脑微血管内皮细胞系上组成性表达，并且这些分子的表达可被内皮素（ET-1、ET-2和ET-3）以剂量和时间依赖性方式上调。数据还表明，ET-1处理可诱导这些细胞上E-选择素的表达。这些发现表明血管活性肽在炎症部位血细胞的募集过程中发挥作用。
