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造血干细胞移植后的内皮功能障碍：基于病理生理学的综述

Endothelial Dysfunction after Hematopoietic Stem Cell Transplantation: A Review Based on Physiopathology.

作者信息

Milone Giuseppe, Bellofiore Claudia, Leotta Salvatore, Milone Giulio Antonio, Cupri Alessandra, Duminuco Andrea, Garibaldi Bruno, Palumbo Giuseppe

机构信息

Divisione di Ematologia e Unita' di Trapianto di Midollo, Azienda Ospedaliera Universitaria Policlinico-San Marco, 95124 Catania, Italy.

出版信息

J Clin Med. 2022 Jan 26;11(3):623. doi: 10.3390/jcm11030623.

DOI:10.3390/jcm11030623
PMID:35160072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8837122/
Abstract

Endothelial dysfunction (ED) is frequently encountered in transplant medicine. ED is an argument of high complexity, and its understanding requires a wide spectrum of knowledge based on many fields of basic sciences such as molecular biology, immunology, and pathology. After hematopoietic stem cell transplantation (HSCT), ED participates in the pathogenesis of various complications such as sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD), graft-versus-host disease (GVHD), transplant-associated thrombotic microangiopathy (TA-TMA), idiopathic pneumonia syndrome (IPS), capillary leak syndrome (CLS), and engraftment syndrome (ES). In the first part of the present manuscript, we briefly review some biological aspects of factors involved in ED: adhesion molecules, cytokines, Toll-like receptors, complement, angiopoietin-1, angiopoietin-2, thrombomodulin, high-mobility group B-1 protein, nitric oxide, glycocalyx, coagulation cascade. In the second part, we review the abnormalities of these factors found in the ED complications associated with HSCT. In the third part, a review of agents used in the treatment of ED after HSCT is presented.

摘要

内皮功能障碍（ED）在移植医学中经常出现。ED是一个高度复杂的问题，对其理解需要基于分子生物学、免疫学和病理学等许多基础科学领域的广泛知识。造血干细胞移植（HSCT）后，ED参与多种并发症的发病机制，如窦性阻塞综合征/静脉闭塞性疾病（SOS/VOD）、移植物抗宿主病（GVHD）、移植相关血栓性微血管病（TA-TMA）、特发性肺炎综合征（IPS）、毛细血管渗漏综合征（CLS）和植入综合征（ES）。在本手稿的第一部分，我们简要回顾了与ED相关的因素的一些生物学方面：黏附分子、细胞因子、Toll样受体、补体、血管生成素-1、血管生成素-2、血栓调节蛋白、高迁移率族B-1蛋白、一氧化氮、糖萼、凝血级联反应。在第二部分，我们回顾了在与HSCT相关的ED并发症中发现这些因素的异常情况。在第三部分，介绍了用于治疗HSCT后ED的药物。

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