里约热内卢献血人群中抗丙型肝炎病毒的流行情况。

Prevalence of anti-hepatitis C virus in the blood donor population of Rio de Janeiro.

作者信息

Vanderborght B O, Reis A M, Rouzere C D, da Silva R S, Yoshida C F, Franco L G, Maertens G, Van Heuverswijn H, Moreira Pereira J

机构信息

Innogenetics, Ghent, Belgium.

出版信息

Vox Sang. 1993;65(2):122-5. doi: 10.1111/j.1423-0410.1993.tb02128.x.

DOI:10.1111/j.1423-0410.1993.tb02128.x

PMID:7692672

Abstract

The prevalence of hepatitis C virus (HCV) antibodies in 2,557 asymptomatic volunteer Brazilian blood donors is reported. Using the line immunoassay (Inno-LIA) as a confirmatory test on ELISA anti-HCV-positive reacting sera, a prevalence rate of 2.7% for anti-HCV positivity was found. By comparison, prevalences of 1.6% for hepatitis B surface antigen, 0.9% for Treponema pallidum, 0.4% for human immunodeficiency virus and 0.04% for Trypanosoma cruzi were observed. Only 57% of the HCV-positive donors had elevated alanine aminotransferase (ALT) levels. Using previous criteria, based on surrogate markers (ALT > or = 50 IU/l and for anti-hepatitis B core antibody), for HCV infection at that time, only 25% of the HCV-positive donations would have been eliminated. In view of the high prevalence of anti-HCV reactivity among the Brazilian blood donor population and the poor reliability of surrogate markers, it is recommended that routine screening for anti-HCV in Brazilian blood donors is introduced.

摘要

报告了2557名无症状巴西自愿献血者中丙型肝炎病毒（HCV）抗体的流行情况。使用线性免疫测定法（Inno-LIA）作为对ELISA抗-HCV阳性反应血清的确认试验，发现抗-HCV阳性的流行率为2.7%。相比之下，观察到乙肝表面抗原的流行率为1.6%，梅毒螺旋体为0.9%，人类免疫缺陷病毒为0.4%，克氏锥虫为0.04%。只有57%的HCV阳性献血者丙氨酸氨基转移酶（ALT）水平升高。按照当时基于替代标志物（ALT≥50 IU/l和抗乙肝核心抗体）的HCV感染标准，只有25%的HCV阳性献血会被排除。鉴于巴西献血人群中抗-HCV反应性的高流行率以及替代标志物的低可靠性，建议对巴西献血者进行抗-HCV常规筛查。