Kleine T O, Hackler R, Zöfel P
Funktionsbereich Neurochemie im Med. Zentrum für Nervenheilkunde, Universität Marburg a.d. Lahn, Germany.
Z Gerontol. 1993 Jul-Aug;26(4):256-9.
Transfer processes of differently sized protein molecules across the blood-brain-barrier (bbb) were studied in "normal" , respectively, diseased elderly humans. Lumbar CSF/serum ratio of albumin contents increased significantly with age in a control group, but it was diminished in patients suffering from inflammatory or non-inflammatory diseases. Ratio of alpha 2-macroglobulin contents increased with age, especially in the diseased elderly. Concentration ratios of lysozyme, orosomucoid, lactoferrin, IgG, IgA and IgM decreased with age in a control group and especially decreased in a patient group. The data are discussed with respect to two different transfer processes which appeared to be altered in age and/or disease processes.
在“正常”和患病的老年人中，研究了不同大小蛋白质分子通过血脑屏障（BBB）的转运过程。对照组中，白蛋白含量的腰椎脑脊液/血清比值随年龄显著增加，但在患有炎症性或非炎症性疾病的患者中该比值降低。α2-巨球蛋白含量的比值随年龄增加，尤其是在患病老年人中。对照组中，溶菌酶、类粘蛋白、乳铁蛋白、IgG、IgA和IgM的浓度比值随年龄降低，在患者组中尤其降低。针对在年龄和/或疾病过程中似乎发生改变的两种不同转运过程对数据进行了讨论。
