Rodríguez-Díaz E, Román C, Yuste M, Morán A G, Aramendi T
Seccion de Dermatologia, Hospital Nuestra Señora de Sonsóles, Avila, España.
Am J Dermatopathol. 1998 Feb;20(1):74-8. doi: 10.1097/00000372-199802000-00015.
Cutaneous lymphadenoma is an uncommon epithelial neoplasm with a controverted adnexal differentiation. We report a typical case of cutaneous lymphadenoma that developed on the left cheek of a 18-year-old woman. Histologically, the neoplasm consisted of lobules of basaloid cells with a peripheral palisading array and filled with a lymphocyte-predmoninant mixed cellular population. Numerous intralobular cells with ample amphopilic cytoplasm, large vesicular nuclei, and prominent nucleoli also were noticed. Immunohistochemical study showed labeling of these Reed-Sternberg-like large cells by antibodies against CD30 antigen. Our findings suggest that cutaneous lymphadenoma is a poorly differentiated adnexal neoplasm, probably trichoblastoma-related, where a singular interaction with several immune cells is established, including activated large lymphocytes analogous to those malignantly proliferating in Hodgkin's disease.
皮肤淋巴结瘤是一种罕见的上皮性肿瘤，其附属器分化存在争议。我们报告了一例发生在一名18岁女性左脸颊的典型皮肤淋巴结瘤病例。组织学上，肿瘤由基底样细胞小叶组成，外周呈栅栏状排列，并充满以淋巴细胞为主的混合细胞群。还发现许多小叶内细胞具有丰富的嗜双色细胞质、大泡状核和明显的核仁。免疫组织化学研究显示，抗CD30抗原抗体标记了这些里德-斯腾伯格样大细胞。我们的研究结果表明，皮肤淋巴结瘤是一种低分化的附属器肿瘤，可能与毛母细胞瘤相关，在该肿瘤中与几种免疫细胞建立了独特的相互作用，包括类似于霍奇金病中恶性增殖的活化大淋巴细胞。
