Sugiyama H, Eda R, Hopp R J, Bewtra A K, Townley R G
Allergic Disease Center, Creighton University School of Medicine, Omaha, Nebraska.
Ann Allergy. 1993 Oct;71(4):391-5.
We investigated the effects of interleukin-3 (IL-3) on histamine release (direct releasing and indirect enhancing effects) from basophils in allergic asthmatic subjects. Interleukin-3 caused direct histamine release (HR) in selected donors (IL-3 responders) and enhanced anti-IgE-induced HR in other IL-3 nonresponders, although both direct releasing and indirect enhancing activities of IL-3 on HR did not coexist with each other. There was a significant correlation between IL-3-induced HR and spontaneous histamine release (r = .8532, P < .0001).
我们研究了白细胞介素-3（IL-3）对过敏性哮喘患者嗜碱性粒细胞组胺释放（直接释放和间接增强作用）的影响。白细胞介素-3在部分供体（IL-3反应者）中引起直接组胺释放（HR），并增强其他IL-3无反应者中抗IgE诱导的HR，尽管IL-3对HR的直接释放和间接增强活性并不共存。IL-3诱导的HR与自发性组胺释放之间存在显著相关性（r = 0.8532，P < 0.0001）。
