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L-nitroarginine, an inhibitor of NO synthase, dramatically worsens limbic epilepsy in rats.

作者信息

Rondouin G, Bockaert J, Lerner-Natoli M

机构信息

CNRS UPR9008, INSERM U249, Laboratoire de Médecine Expérimentale, Institut de Biologie, Montpellier, France.

出版信息

Neuroreport. 1993 Sep 3;4(10):1187-90.

PMID:7693012
Abstract

During status epilepticus provoked by an intra-amygdala injection of kainic acid, the severity of seizures and of consequent neuronal damage was considerably increased in rats treated with L-NOARG, at a dose which completely inhibited NO synthesis. We propose that the effects of L-NOARG could be related to the loss of a retrograde inhibition exerted by NO on NMDA receptors. The complete suppression of NO formation in the brain finally facilitated the development and the generalization of seizures and their neurotoxic consequences.

摘要

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