一氧化氮合酶的抑制作用显著增强了大鼠中由海藻酸和毛果芸香碱诱导的癫痫发作。
Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
作者信息
Maggio R, Fumagalli F, Donati E, Barbier P, Racagni G, Corsini G U, Riva M
机构信息
Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
出版信息
Brain Res. 1995 May 8;679(1):184-7. doi: 10.1016/0006-8993(95)00217-e.
PMID:7544223
Abstract
We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
摘要
我们研究了在一氧化氮合酶抑制剂处理的大鼠中，由海藻酸和毛果芸香碱诱发的惊厥严重程度是否会发生改变。我们发现，用左旋硝基精氨酸甲酯进行慢性处理（4天）会大大增强由这两种惊厥剂诱发的癫痫发作，这表明一氧化氮在调节癫痫发作诱导和传播的机制中可能发挥作用。
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