Maggio R, Fumagalli F, Donati E, Barbier P, Racagni G, Corsini G U, Riva M
Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
Brain Res. 1995 May 8;679(1):184-7. doi: 10.1016/0006-8993(95)00217-e.
We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
我们研究了在一氧化氮合酶抑制剂处理的大鼠中，由海藻酸和毛果芸香碱诱发的惊厥严重程度是否会发生改变。我们发现，用左旋硝基精氨酸甲酯进行慢性处理（4天）会大大增强由这两种惊厥剂诱发的癫痫发作，这表明一氧化氮在调节癫痫发作诱导和传播的机制中可能发挥作用。
