Pestarino M, Lucaroni B, Distefano S
Istituto di Anatomia Comparata, Università di Genova, Italy.
Eur J Histochem. 1993;37(3):225-32.
FMRFamide and bovine pancreatic polypeptide (BPP) immunoreactivities were detected in the cerebral ganglion and in the alimentary tract of the protochordate ascidian Styela plicata. Neurons expressing immunostain to FMRFamide were mainly found in the cortical zone of the ganglion and a network of immunoreactive beaded nerve fibers was present in the neuropil. Co-localization of FMRFamide- and BPP-like materials was demonstrated in few nerve cell bodies and both peptides likely play a neurotransmitter role. Parallel, endocrine-like cells containing FMRFamide-like materials were distributed among the esophageal and gastric epithelia, whereas no PP immunostaining was found. The tetrapeptide could be involved in the regulation of the digestive processes by means of endocrine and/or paracrine mechanisms.
在原索动物皱瘤海鞘的脑神经节和消化道中检测到了FMRF酰胺和牛胰多肽（BPP）免疫反应性。表达FMRF酰胺免疫染色的神经元主要存在于神经节的皮质区，神经纤维网中存在免疫反应性念珠状神经纤维。在少数神经细胞体中证实了FMRF酰胺样物质和BPP样物质的共定位，这两种肽可能都发挥神经递质的作用。同时，含有FMRF酰胺样物质的类内分泌细胞分布在食管和胃上皮之间，而未发现PP免疫染色。这种四肽可能通过内分泌和/或旁分泌机制参与消化过程的调节。
