Margolskee R F
Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110-1199.
Curr Opin Neurobiol. 1993 Aug;3(4):526-31. doi: 10.1016/0959-4388(93)90051-y.
The recent application of molecular biological techniques to taste cells has led to the identification and cloning of a number of proteins that are involved in signal transduction. Some of these are expressed only in taste cells, whereas others are expressed at higher levels in taste cells than in other, non-sensory lingual cells. Among these proteins are several G protein alpha subunits, of which alpha gustducin is particularly interesting because of its similarity to the alpha transducins expressed in the visual system, suggesting that there are similarities in taste and visual transduction mechanisms.
分子生物学技术最近在味觉细胞中的应用，已导致了一些参与信号转导的蛋白质的鉴定和克隆。其中一些仅在味觉细胞中表达，而另一些在味觉细胞中的表达水平高于其他非感觉性舌细胞。这些蛋白质中有几种G蛋白α亚基，其中α-味导素特别有趣，因为它与视觉系统中表达的α-转导蛋白相似，这表明味觉和视觉转导机制存在相似性。
