Owen R J
Commun Dis Rep CDR Rev. 1993 Mar 26;3(4):R51-6.
Helicobacter pylori colonises the human gastroduodenal mucosa, causes chronic active gastritis, is a co-factor for the development of duodenal ulceration, and is associated with gastric ulceration and gastric cancer. As there are no readily available typing schemes for identification of individual isolates, little is known about the acquisition, distribution and frequency of particular strains of H. pylori in different populations, communities and families. Molecular (DNA) typing studies carried out over the last three years on isolates from the United Kingdom and other countries at the National Collection of Type Cultures (NCTC) show considerable diversity in strains from different individuals, yet multiple isolates from different gastroduodenal sites in an individual are usually identical. Major routes of infection have not been established, but similarities of DNA sequence between isolates from some family members, and the serological data, indicate that some H. pylori infections are acquired in households during childhood. Molecular typing will have an important role in future studies on transmission.
幽门螺杆菌寄居于人类胃十二指肠黏膜，可引发慢性活动性胃炎，是十二指肠溃疡发病的一个协同因素，还与胃溃疡及胃癌相关。由于目前尚无简便易行的分型方法用于鉴定单个分离株，因此对于幽门螺杆菌特定菌株在不同人群、社区及家庭中的获得、分布及频率了解甚少。过去三年在英国及其他国家的国家典型培养物保藏中心（NCTC）对分离株开展的分子（DNA）分型研究表明，来自不同个体的菌株具有相当大的多样性，但同一个体不同胃十二指肠部位的多个分离株通常是相同的。主要感染途径尚未明确，但一些家庭成员分离株之间的DNA序列相似性以及血清学数据表明，部分幽门螺杆菌感染是在儿童期于家庭中获得的。分子分型在未来的传播研究中将发挥重要作用。
