血清素耗竭剂，5,7-二羟基色胺和对氯苯丙氨酸，会导致成年蜗牛中枢神经系统出现轴突发芽。
Serotonin depletors, 5,7-dihydroxytryptamine and p-chlorophenylalanine, cause sprouting in the CNS of the adult snail.
作者信息
Baker M W, Vohra M M, Croll R P
机构信息
Department of Physiology and Biophysics, Dalhousie University, Halifax, NS, Canada.
出版信息
Brain Res. 1993 Oct 1;623(2):311-5. doi: 10.1016/0006-8993(93)91444-w.
The effects of 5,7-dihydroxytryptamine (5,7-DHT) and p-chlorophenylalanine (PCPA) on neuronal morphology were investigated in Achatina fulica by backfilling the cerebrobuccal connective with nickel-lysine. Backfilling 21 days following injections of either 5,7-DHT or PCPA revealed supernumerary staining of fibers in different pathways of the cerebral and buccal ganglia and novel staining of somata in the cerebral ganglia. HPLC measurements confirm that drug treatments led to a 30-46% depletion of serotonin (5-HT) in the buccal ganglia. These results support the role suggested for 5-HT as a neuritogenic modulator and additionally advise caution in the use of pharmacological depletors in studies examining serotonergic function.
通过用镍赖氨酸对脑颊神经连合进行逆向填充，研究了5,7-二羟基色胺（5,7-DHT）和对氯苯丙氨酸（PCPA）对非洲大蜗牛神经元形态的影响。在注射5,7-DHT或PCPA 21天后进行逆向填充，结果显示在脑和颊神经节的不同通路中纤维出现额外染色，并且在脑内神经节中出现了新的胞体染色。高效液相色谱测量证实，药物处理导致颊神经节中5-羟色胺（5-HT）减少了30%-46%。这些结果支持了5-HT作为神经突生成调节剂的作用，此外还建议在研究5-羟色胺能功能时谨慎使用药理学耗竭剂。
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