Gandia J A, De Las Heras S, García M, Giménez-Amaya J M
Departamento de Traumatología y Cirugía Ortopédica, Hospital Ramón y Cajal, Madrid, Spain.
Brain Res Bull. 1993;32(4):351-8. doi: 10.1016/0361-9230(93)90199-l.
This study was designed to explore the thalamic output of the globus pallidus (GP) and the pars reticulata (SNR) of the substantia nigra (SN) upon the reticular thalamic nucleus (Rt) in the rat. Thus, 13 animals were deeply anesthetized and stereotaxically injected with horseradish peroxidase (HRP) conjugated with wheat germ agglutinin (HRP-WGA) mixed with HRP free in different portions of GP and SN. Next, we evaluated the anterograde terminal labeling in the rostral two-thirds of Rt. Confirmatory results were obtained in our case material about the entity of GP reticular projections, and some new data are presented here regarding the projections from GP and SNR upon Rt. Among them we emphasize the following for the rostral two-thirds of this thalamic nucleus: a) the projections from GP are more abundant than those arising from SNR; b) a dorsoventral topographical design appears to be clear in the organization of the afferent connections from GP to Rt; c) SNR projects more abundantly to the ventral sectors of Rt; and d) the central core of Rt is more innervated by GP than by SNR, which innervates Rt mainly in its peripheral portions. These results raise the possibility of multiple and differentiated assignments of the output nuclei of the basal ganglia upon the thalamus and its connectivity.
本研究旨在探究大鼠苍白球（GP）和黑质网状部（SNR）对丘脑网状核（Rt）的丘脑输出。因此，对13只动物进行深度麻醉，并在立体定位下将与小麦胚芽凝集素结合的辣根过氧化物酶（HRP-WGA）与游离的HRP混合，注射到GP和SN的不同部位。接下来，我们评估了Rt前三分之二区域的顺行终末标记。在我们的病例材料中获得了关于GP网状投射实体的确证结果，并在此展示了一些关于GP和SNR向Rt投射的新数据。对于该丘脑核的前三分之二区域，我们着重强调以下几点：a）来自GP的投射比来自SNR的投射更丰富；b）从GP到Rt的传入连接组织中，背腹向的拓扑设计似乎很清晰；c）SNR向Rt的腹侧区域投射更为丰富；d）GP对Rt中央核心的支配比SNR更多，SNR主要支配Rt的周边部分。这些结果增加了基底神经节输出核在丘脑及其连接上存在多种不同分配的可能性。
