Burleigh D E, Borman R A
Department of Pharmacology, Queen Mary and Westfield College, London, UK.
Eur J Pharmacol. 1993 Sep 7;241(1):125-8. doi: 10.1016/0014-2999(93)90943-c.
5-Hydroxytryptamine (5-HT) increases short-circuit current when added to the serosal side of human isolated ileal mucosa; mucosally applied 5-HT was ineffective. Tetrodotoxin reduced both basal short-circuit current and increases in short-circuit current due to electrical field stimulation of mucosal nerves. However, neither tetrodotoxin, ondansetron nor methysergide plus ketanserin affected 5-HT induced increases in short-circuit current. Application of SDZ 205-557 (2-diethylaminoethyl-(2-methoxy-4-amino-5-chloro) benzoate) to the tissue caused a significant increase in the concentration ratio between two successive 5-HT response curves. It is concluded that the effect of 5-HT on short-circuit current of human ileal mucosa appears to be due to stimulation of a 5-HT4 receptor.
5-羟色胺（5-HT）添加至人离体回肠黏膜浆膜侧时可增加短路电流；经黏膜应用5-HT则无效。河豚毒素可降低基础短路电流以及因黏膜神经电场刺激所致的短路电流增加。然而，河豚毒素、昂丹司琼以及甲基麦角新碱加酮色林均不影响5-HT诱导的短路电流增加。向组织应用SDZ 205-557（2-二乙氨基乙基-（2-甲氧基-4-氨基-5-氯）苯甲酸酯）导致两条连续的5-HT反应曲线之间的浓度比显著增加。结论是，5-HT对人回肠黏膜短路电流的作用似乎是由于对5-HT4受体的刺激。
