Borman R A, Burleigh D E
Department of Pharmacology, Queen Mary and Westfield College, London.
Br J Pharmacol. 1993 Nov;110(3):927-8. doi: 10.1111/j.1476-5381.1993.tb13901.x.
5-Hydroxytryptamine increases transmucosal short-circuit current across human isolated small intestinal mucosa. The competitive 5-HT4 antagonist, DAU 6285 evoked a concentration-dependent, dextral and parallel shift of the concentration-response curve to 5-HT, with no alteration of the maximum response. Schild analysis of this antagonism produced a Schild regression with a slope of 1.00 and an apparent pA2 estimate of 6.17. It appears that a 5-HT4 receptor may mediate the short-circuit current response of human small intestinal mucosa to 5-HT.
5-羟色胺可增加人离体小肠黏膜的跨黏膜短路电流。竞争性5-HT4拮抗剂DAU 6285引起浓度依赖性、右旋和平行的5-HT浓度-反应曲线移位,最大反应无改变。对这种拮抗作用进行Schild分析得出斜率为1.00的Schild回归和6.17的表观pA2估计值。似乎5-HT4受体可能介导人小肠黏膜对5-HT的短路电流反应。