Meir A, Edry-Schiller J, Habartova A, Mahinson H, Rahamimoff R
Department of Physiology, Bernard Katz Minerva Center on Cell Biophysics, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Isr J Med Sci. 1993 Sep;29(9):517-29.
Synaptic transmission is a key element in neuronal communication in the nervous system. It is determined by two basic sets of processes: release of transmitter from the presynaptic nerve ending and the detection and response by the postsynaptic cell. The release of transmitter is crucially dependent on the interplay among the ion channels in the surface membrane of the presynaptic terminal. In this article we describe the methods used in the study of the ion channels in secretory nerve endings and present the 16 calcium, sodium, chloride, cationic and potassium ion channels discovered in various preparations. We speculate about the physiological and pathophysiological roles of some of these ion channels.
突触传递是神经系统中神经元通讯的关键要素。它由两组基本过程决定：神经递质从突触前神经末梢释放，以及突触后细胞的检测与反应。神经递质的释放关键取决于突触前末梢表面膜中离子通道之间的相互作用。在本文中，我们描述了用于研究分泌性神经末梢中离子通道的方法，并介绍了在各种制剂中发现的16种钙、钠、氯、阳离子和钾离子通道。我们推测了其中一些离子通道的生理和病理生理作用。
