Zefirov A L, Gafurov B Sh
Biofizika. 1996 Mar-Apr;41(2):384-92.
The Hodgkin-Huxley's equations of unmyelinated nerve fiber's electric behaviour has been used to create model of nerve endings electrogenesis. The Eler's integration method has been applied to solve the partial differential equation system which describes the spread of excitation in nerve ending. The effect of nonhomogeneous distribution densities of ionic channels along nerve ending on the ionic currents were simulated. The comparison of computed curves with nerve ending responses recorded by extracellular electrodes was performed. It was shown that the better match between simulated and recorded responses observes during densities' decrease potential-dependent sodium, potassium and calcium-activated potassium channels according to exponent along the nerve ending without changes of calcium channels density. As the result the amplitude and time-course of spread action potential, calcium current and transmitter release along the nerve ending appear to be changed.
霍奇金-赫胥黎关于无髓神经纤维电行为的方程已被用于创建神经末梢电发生模型。采用埃勒积分方法求解描述神经末梢兴奋传播的偏微分方程组。模拟了沿神经末梢离子通道非均匀分布密度对离子电流的影响。将计算曲线与细胞外电极记录的神经末梢反应进行了比较。结果表明，当沿神经末梢按指数降低电压依赖性钠、钾和钙激活钾通道的密度而钙通道密度不变时，模拟反应与记录反应之间的匹配度更好。结果，沿神经末梢传播动作电位的幅度和时间进程、钙电流和递质释放似乎发生了变化。
