Trevor P B, Saunders G K, Waldron D R, Leib M S
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061.
J Am Vet Med Assoc. 1993 Aug 1;203(3):406-9.
Stage-3 extramedullary plasmacytoma of the large intestine was diagnosed in an 8-year-old Labrador Retriever. Three primary tumors were located in the colon and rectum, with metastasis to local lymph nodes and the spleen. The disease was associated with a monoclonal serum protein spike identified as IgG. Treatment consisted of surgical excision followed by chemotherapy, using melphalan and prednisone. The dog remained free from clinical signs of disease and adverse effects of the chemotherapy at 9 months. Findings in this dog indicated that extramedullary plasmacytoma may be an aggressive disease, associated with spread to distant sites and monoclonal gammopathy.
一只8岁的拉布拉多猎犬被诊断患有3期大肠髓外浆细胞瘤。三个原发性肿瘤位于结肠和直肠，已转移至局部淋巴结和脾脏。该疾病与一种鉴定为IgG的单克隆血清蛋白峰有关。治疗包括手术切除，随后使用美法仑和泼尼松进行化疗。这只狗在9个月时没有出现疾病的临床症状和化疗的不良反应。这只狗的检查结果表明，髓外浆细胞瘤可能是一种侵袭性疾病，与远处转移和单克隆丙种球蛋白病有关。
