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[自然复发性流产的免疫治疗。妊娠第3周输注配偶白细胞的价值]

[Immunological treatment of spontaneous repeated abortions. The value of transfusing the partner's leukocytes in the third week of gestation].

作者信息

Sagot P, Bignon J D, Cesbron A, Laurent F X, Adjou C, Muller J Y

机构信息

Département de Gynécologie-Obstétrique et Biologie de la Reproduction, CHRU, Nantes.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1993;22(5):471-5.

PMID:7693793
Abstract

Twenty-two nulli- all primipara who had had previous repeated spontaneous abortions and who did not have anti-HLA antibodies for the partner, received immunological treatment consisting of a single transfusion of the partner's lymphocytes in the third week of pregnancy, and giving natural progesterone supplements after the kinetic of Beta-HCG in the plasma had been assessed. The number of pregnancies which went to terme (94% success) was significantly better than those obtained in our first protocol which was to give one to three transfusions of the partner's lymphocytes before the pregnancy started (58% success rare after 24 treatments). Apart from obtaining much better results the second protocol made it possible to avoid giving a significant number of useless transfusions (22% of pre-conceptual transfusions were not followed by a pregnancy at all).

摘要

22例曾有反复自然流产史且对伴侣无抗HLA抗体的未育初产妇,在妊娠第3周接受了由单次输注伴侣淋巴细胞组成的免疫治疗,并在评估血浆中β-HCG动态变化后给予天然孕酮补充剂。足月妊娠的数量(成功率94%)显著高于我们第一个方案所获得的结果,第一个方案是在妊娠开始前输注1至3次伴侣淋巴细胞(24次治疗后成功率为58%,很少见)。除了获得更好的结果外,第二个方案还避免了大量无用的输注(22%的孕前输注根本没有导致妊娠)。

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