Staroniewicz Z
Katedra Mikrobiologii Wydziału Medycyny Weterynaryjnej AR, Wrocławiu.
Med Dosw Mikrobiol. 1993;45(1):103-6.
The study was aimed at investigation of reducing ability of nitrotetrazol blue (NBT) by peritoneal fluid macrophages and spleen and mesenteric lymph node during experimental yersiniosis. Investigations were carried on BALB/c mice infected perorally by the dose of 10(6) of live, virulent cells of Y. enterocolitica. It was found that clear increase of metabolic activity in macrophages occurred between 3 and 12 day after infection, in spleen lymphocytes between 6 and 9 day, whereas it was noted in mesenteric lymph node between 6 and 15 day after infection. Maximal stimulation of macrophages was observed at the 6th day of lymphocytes on 9th day after infection. These results suggest that macrophages are the first cells which react to infection with Y. enterocolitica. Activity of spleen and mesenteric lymph node lymphocytes during first days of infection appeared relatively small.
本研究旨在调查实验性耶尔森菌病期间腹膜液巨噬细胞以及脾脏和肠系膜淋巴结对硝基四氮唑蓝（NBT）的还原能力。对经口感染10⁶个活的、有毒力的小肠结肠炎耶尔森菌细胞剂量的BALB/c小鼠进行了研究。结果发现，感染后3至12天巨噬细胞的代谢活性明显增加，感染后6至9天脾脏淋巴细胞的代谢活性增加，而肠系膜淋巴结的代谢活性在感染后6至15天增加。感染后第6天观察到巨噬细胞受到最大刺激，感染后第9天淋巴细胞受到最大刺激。这些结果表明，巨噬细胞是对小肠结肠炎耶尔森菌感染作出反应的首批细胞。感染初期脾脏和肠系膜淋巴结淋巴细胞的活性相对较小。
