Suto T
Department of Pathology I, Iwate Medical University, Morioka, Japan.
Nihon Geka Gakkai Zasshi. 1993 Oct;94(10):1100-7.
In order to investigate the diagnostic and prognostic utility, I measured the number and area of silver stained nucleolar organizer region proteins (Ag-NOR) in sections of surgical specimens from 71 patients with gallbladder diseases. The disease consisted of cholecystolithiasis without congenital anomaly in 20 patients, congenital biliary dilatation with anomalous arrangement of pancreaticobiliary ducts in 10, cholecystolithiasis with anomalous arrangement of pancreaticobiliary ducts without congenital biliary dilatation in 4, adenoma of the gallbladder in 5, and carcinoma of the gallbladder in 36. There was a significant difference between carcinoma and benign lesions in number of Ag-NOR, indicating that it may be a useful marker in discriminating cholecystopathic malignancy. The number of Ag-NOR was closely related with depth of invasion in carcinoma of the gallbladder, and there was a significant difference between carcinoma which invaded the tunica serosa and that which did not. The number of Ag-NOR was significantly lower in papillary adenocarcinoma than in moderately differentiated adenocarcinoma or adenosquamous carcinoma, suggesting that the proliferative activity and biological malignant potential are lower in the former.
为了研究其诊断和预后价值，我测量了71例胆囊疾病患者手术标本切片中银染核仁组成区蛋白（Ag-NOR）的数量和面积。疾病包括20例无先天性异常的胆囊结石患者、10例先天性胆管扩张伴胰胆管异常排列患者、4例无先天性胆管扩张但胰胆管异常排列的胆囊结石患者、5例胆囊腺瘤患者以及36例胆囊癌患者。Ag-NOR数量在癌与良性病变之间存在显著差异，表明它可能是鉴别胆囊疾病恶性程度的有用标志物。Ag-NOR数量与胆囊癌的浸润深度密切相关，浸润至浆膜层的癌与未浸润至浆膜层的癌之间存在显著差异。乳头状腺癌的Ag-NOR数量显著低于中分化腺癌或腺鳞癌，提示前者的增殖活性和生物学恶性潜能较低。
