Misra V, Misra S P, Dwivedi M, Gupta S C
Department of Pathology and Gastoenterology, M.L.N. Medical College, Allahabad.
Indian J Pathol Microbiol. 1995 Oct;38(4):383-8.
Sections from eighty nine specimens of gall bladder including 40 cases of chronic cholecystitis, 9 dysplasia 15 well differentiated adenocarcinoma, 14 moderately differentiated adenocarcinoma and 11 poorly differentiated adenocarcinomas were studied for argyrophilic nucleolar organizer regions (AgNOR's). The difference between mean +/- SD NOR counts of chronic cholecystitis (1.97 +/- 0.28), dysplasia (5.6 +/- 0.88) well differentiated adenocarcinoma (7.2 +/- 0.30) and moderately differentiated adenocarcinoma (8.0 +/- 0.63) was statistically significant (p < 0.001). NOR counts of poorly differentiated adenocarcinoma (8.5 +/- 0.78) were higher than moderately differentiated carcinoma but the difference was not statistically significant. Despite the significant difference in the mean values, a considerable overlap in the NOR counts of individual cases of different groups was observed suggesting that though NOR counts can not act as a specific diagnostic parameter for diagnosis of early carcinoma and dysplasia in isolated cases, they may prove to be a good adjunct to already existing parameters like imaging techniques or cytology.
对89个胆囊标本进行了研究，其中包括40例慢性胆囊炎、9例发育异常、15例高分化腺癌、14例中分化腺癌和11例低分化腺癌，以检测嗜银核仁组织区（AgNOR's）。慢性胆囊炎（1.97±0.28）、发育异常（5.6±0.88）、高分化腺癌（7.2±0.30）和中分化腺癌（8.0±0.63）的平均±标准差NOR计数之间的差异具有统计学意义（p<0.001）。低分化腺癌（8.5±0.78）的NOR计数高于中分化癌，但差异无统计学意义。尽管平均值存在显著差异，但不同组个别病例的NOR计数有相当大的重叠，这表明尽管NOR计数不能作为孤立病例早期癌和发育异常诊断的特异性诊断参数，但它们可能被证明是现有参数（如图像技术或细胞学）的良好辅助手段。
