Mathisen P M, Pease S, Garvey J, Hood L, Readhead C
Division of Biology, California Institute of Technology, Pasadena 91125.
Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10125-9. doi: 10.1073/pnas.90.21.10125.
We have identified a myelin basic protein (MBP) isoform in mouse embryos that includes an exon upstream of the usual transcription initiation site. This isoform, embryonic-neonatal MBP (E-MBP), is expressed at the protein level in the embryonic nervous system at a time when other MBP isoforms are not detected. In addition to the central and peripheral nervous systems of the embryo and neonate, the thymus, spleen, and testes also express E-MBP at the protein level. The expression of E-MBP in cell types distinct from the nervous system strongly suggests that this MBP isoform has a role apart from the formation of myelin.
我们在小鼠胚胎中鉴定出一种髓鞘碱性蛋白（MBP）亚型，其包含一个位于通常转录起始位点上游的外显子。这种亚型，即胚胎 - 新生期MBP（E - MBP），在胚胎神经系统中以蛋白质水平表达，而此时其他MBP亚型未被检测到。除了胚胎和新生儿的中枢和外周神经系统外，胸腺、脾脏和睾丸也在蛋白质水平表达E - MBP。E - MBP在与神经系统不同的细胞类型中的表达强烈表明，这种MBP亚型除了参与髓鞘形成外还具有其他作用。
