Cabié A, Franck N, Gaudric M, Gorin I, Lessana-Leibowitch M, Escande J P
Service de Dermatologie et Vénéréologie, Hôpital Cochin-Tarnier, Paris.
Ann Dermatol Venereol. 1993;120(4):299-301.
We report the case of a 46-year old woman who, over a 12-year period, had 6 episodes of nodular panniculitis. Each lesion regressed and disappeared within four to six weeks. Fistulization before formation of a cupula-shaped scar was observed on two occasions. These episodes of hypodermitis seemed to be isolated when they began, but histological examination of the skin showed cytosteatonecrosis of the hypodermis pointing to a pancreatic origin. Signs of pancreatic abnormality appeared progressively: first an increase of amylasaemia concomitant with the cutaneous flares, then morphological abnormalities of the pancreatic ducts suggestive of pancreas divisum, and finally dilatation of the main pancreatic duct associated with upstream pancreatitis. No radical treatment of the pancreatic abnormality was carried out.
我们报告了一例46岁女性的病例，该患者在12年期间出现了6次结节性脂膜炎发作。每个病变在四到六周内消退并消失。有两次观察到在形成杯状瘢痕之前出现了瘘管形成。这些皮下炎症发作开始时似乎是孤立的，但皮肤组织学检查显示皮下脂肪细胞坏死，提示胰腺起源。胰腺异常的体征逐渐出现：首先是淀粉酶血症升高与皮肤发作同时出现，然后是胰腺导管形态异常提示胰腺分裂，最后是主胰管扩张并伴有上游胰腺炎。未对胰腺异常进行根治性治疗。
