Pardoll D M
Johns Hopkins University School of Medicine, Baltimore.
Curr Opin Immunol. 1993 Oct;5(5):719-25. doi: 10.1016/0952-7915(93)90127-e.
When a cancer grows in an individual, the immune system has either failed to recognize its antigens or failed to effectively respond. Increasing evidence for the existence of tumor antigens that are recognized by T cells provides a direct rationale for the design of novel strategies to either enhance tumor immunogenicity by genetic modification or utilize recombinant or peptide vaccines in cases where the relevant tumor antigens have been specifically identified.
当个体发生癌症时，免疫系统要么未能识别其抗原，要么未能做出有效反应。越来越多的证据表明存在可被T细胞识别的肿瘤抗原，这为设计新策略提供了直接依据，这些策略要么通过基因改造增强肿瘤免疫原性，要么在已明确鉴定出相关肿瘤抗原的情况下使用重组疫苗或肽疫苗。
