玻连蛋白及其受体。
Vitronectin and its receptors.
作者信息
Felding-Habermann B, Cheresh D A
机构信息
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037.
出版信息
Curr Opin Cell Biol. 1993 Oct;5(5):864-8. doi: 10.1016/0955-0674(93)90036-p.
The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3. Cell interaction with vitronectin may induce spreading and migration and have an effect on cell growth and differentiation in specific processes, such as tumor growth and metastasis, wound healing, bone resorption and viral infection.
细胞外基质蛋白玻连蛋白被表达四种已知玻连蛋白受体中至少一种的细胞识别为黏附底物，这四种受体为整合素αvβ1、αvβ3、αvβ5或αIIbβ3。细胞与玻连蛋白的相互作用可能诱导细胞铺展和迁移，并在特定过程中对细胞生长和分化产生影响，如肿瘤生长和转移、伤口愈合、骨吸收及病毒感染。
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