伴有绒毛状淋巴细胞的脾淋巴瘤，具有CD5+、CD11c+ B细胞表型。

Splenic lymphoma with villous lymphocytes with CD5+, CD11c+ B-cell phenotype.

作者信息

Miyawaki S, Machii T, Hirabayashi H, Sakura T, Shiozaki H, Yashiro K, Murakami H, Tsuchiya J, Kashiwabara K, Kitani T

机构信息

Department of Internal Medicine, Saiseikai Maebashi Hospital, Gunma, Japan.

出版信息

Intern Med. 1993 Jun;32(6):472-5. doi: 10.2169/internalmedicine.32.472.

DOI:10.2169/internalmedicine.32.472

PMID:7694693

Abstract

A 64-year-old male suffered from splenomegaly without lymphadenopathy. His WBC count on admission was 6.1 x 10(9)/l with 55% abnormal lymphocytes. No monoclonal gammopathy was detected. Abnormal cells shown in films usually had relatively abundant cytoplasm with serrated edges. Under phase-contrast microscopy, the cells displayed short, needle-like processes. The immunophenotype of peripheral blood mononuclear cells were CD19+, CD20+, CD11c+, FMC7+, CD5+, CD10-, CD25- and SIg+. The spleen histology showed a distinctive pattern of white pulp infiltration by abnormal lymphocytes with features of plasma cell differentiation. These findings were compatible with the features of splenic lymphoma with villous lymphocytes.

摘要

一名64岁男性患有脾肿大，但无淋巴结病。入院时他的白细胞计数为6.1×10⁹/L，其中55%为异常淋巴细胞。未检测到单克隆丙种球蛋白病。血涂片显示的异常细胞通常具有相对丰富的细胞质，边缘呈锯齿状。在相差显微镜下，这些细胞呈现出短的针状突起。外周血单个核细胞的免疫表型为CD19⁺、CD20⁺、CD11c⁺、FMC7⁺、CD5⁺、CD10⁻、CD25⁻和表面免疫球蛋白阳性。脾脏组织学显示白髓有异常淋巴细胞浸润的独特模式，并具有浆细胞分化特征。这些发现符合伴有绒毛状淋巴细胞的脾淋巴瘤的特征。