细胞角蛋白19片段：非小细胞肺癌的一种新标志物。
Cytokeratin 19 fragments: a new marker for non-small-cell lung cancer.
作者信息
Stieber P, Bodenmüller H, Banauch D, Hasholzner U, Dessauer A, Ofenloch-Hähnle B, Jaworek D, Fateh-Moghadam A
机构信息
Institut für Klinische Chemie Klinikum Grosshadern, Ludwig-Maximilian University, Munich, Germany.
出版信息
Clin Biochem. 1993 Aug;26(4):301-4. doi: 10.1016/0009-9120(93)90129-t.
We developed a new and automated assay for the detection of lung cancer associated cytokeratin 19 fragments in patients' sera/plasma. This new tumour marker assay CYFRA 21-1 was evaluated in technical and clinical studies using the multibatch analysers ES 300 and ES 600 from Boehringer Mannheim GmbH. The analytical performance was shown to be excellent. The clinical data from 2,037 patients demonstrate that for non-small-cell lung carcinoma CYFRA 21-1 has a higher diagnostic sensitivity compared to the established markers. Mainly for squamous cell carcinoma CYFRA 21-1 was superior (60%) to CEA (18%) or SCC (31%).
我们开发了一种新型自动化检测方法，用于检测患者血清/血浆中与肺癌相关的细胞角蛋白19片段。使用勃林格殷格翰公司的多批次分析仪ES 300和ES 600，在技术和临床研究中对这种新型肿瘤标志物检测方法CYFRA 21-1进行了评估。结果表明其分析性能优异。来自2037名患者的临床数据显示，对于非小细胞肺癌，CYFRA 21-1的诊断敏感性高于已有的标志物。主要针对鳞状细胞癌，CYFRA 21-1（60%）优于癌胚抗原（CEA，18%）或鳞状细胞癌抗原（SCC，31%）。
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