Li Y L, Ruo S L, Tong Z, Ma Q R, Liu Z L, Ye K L, Zhu Z Y, McCormick J B, Fisher-Hoch S P, Xu Z Y
Department of Epidemiology, School of Public Health, Shanghai Medical University, China.
Am J Trop Med Hyg. 1995 Mar;52(3):247-51. doi: 10.4269/ajtmh.1995.52.247.
Apodemus agrarius was trapped in the fields and Rattus norvegicus was trapped within the houses in the villages of Jiande County, a region in the Zhejiang Province of China endemic for hemorrhagic fever with renal syndrome (HFRS). Antibodies to hantaviruses were detected in three (16.7%) of 18 A. agrarius and 12 (13.5%) of 89 R. norvegicus, whereas hantavirus antigens were detected in the lung tissues of four (22.2%) of 18 and nine (10.1%) of 89 of these rodents, respectively. Three hantaviruses, one from A. agrarius and two from R. norvegicus, were isolated and found to be antigenically similar to Hantaan and Seoul serotype viruses, respectively. A serologic study of 437 clinically defined HFRS patients conducted in Jiande County in 1988 revealed that the ratio of Hantaan (72.5%) to Seoul (26.8%) serotype virus infections was 2.7:1. Two epidemic seasons were found, with a major peak in November and a minor peak in June, and both were associated with Hantaan serotype virus infections that coincided with two seasonal peaks of the A. agrarius population and local agricultural activities in the fields. Seoul serotype virus infections occurred with a small peak during the months of December through May, in which in-house activities were dominant. All data suggested that Jiande County was an area endemic for HFRS, predominantly of the Hantaan virus serotype, combined with Seoul serotype virus infections.
黑线姬鼠在浙江省建德县农村的田野中捕获，褐家鼠在村庄的房屋内捕获，建德县是中国浙江省肾综合征出血热（HFRS）的地方性流行区。在18只黑线姬鼠中有3只（16.7%）和89只褐家鼠中有12只（13.5%）检测到汉坦病毒抗体，而在这些啮齿动物中，18只中的4只（22.2%）和89只中的9只（10.1%）的肺组织中检测到汉坦病毒抗原。分离出3株汉坦病毒，其中1株来自黑线姬鼠，2株来自褐家鼠，发现它们在抗原性上分别与汉滩型和汉城型病毒相似。1988年在建德县对437例临床诊断为HFRS的患者进行的血清学研究表明，汉滩型（72.5%）与汉城型（26.8%）病毒感染的比例为2.7:1。发现有两个流行季节，11月有一个主要高峰，6月有一个次要高峰，这两个高峰均与汉滩型病毒感染有关，与黑线姬鼠种群的两个季节性高峰和田间当地农业活动相吻合。汉城型病毒感染在12月至5月期间出现一个小高峰，在此期间室内活动占主导。所有数据表明，建德县是HFRS的地方性流行区，主要为汉滩型病毒血清型，同时伴有汉城型病毒感染。
