Elfant A B, Levine S M, Peikin S R, Cencora B, Méndez L, Pello M J, Atabek U M, Alexander J B, Spence R K, Camishion R C
Department of Medicine, University of Medicine and Dentistry of New Jersey, Cooper Hospital/University Medical Center, Camden.
Am J Surg. 1995 Apr;169(4):430-2. doi: 10.1016/s0002-9610(99)80192-5.
A study was performed to determine bioavailability of medication delivered via nasogastric tube in patients after abdominal surgery.
Acetaminophen (20 mg/kg) was administered to each patient per os at least 48 hours prior to abdominal surgery and via nasogastric tube 3 hours postoperatively. The nasogastric tube was clamped for 30 minutes after drug administration, prior to resuming suction. Serum levels of acetaminophen were measured 0, 40, and 90 minutes after each dose.
Acetaminophen levels were significantly lower (P < 0.001) when the drug was administered via nasogastric tube postoperatively.
Decreased bioavailability of medications delivered via nasogastric tube may have important clinical implications and should be taken into consideration during the postoperative period.
开展了一项研究以确定腹部手术后经鼻胃管给药的药物生物利用度。
在腹部手术前至少48小时给每位患者口服对乙酰氨基酚（20毫克/千克），术后3小时经鼻胃管给药。给药后将鼻胃管夹闭30分钟，然后恢复抽吸。在每次给药后0、40和90分钟测量血清对乙酰氨基酚水平。
术后经鼻胃管给药时，对乙酰氨基酚水平显著较低（P < 0.001）。
经鼻胃管给药的药物生物利用度降低可能具有重要的临床意义，在术后期间应予以考虑。
