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人细胞中A1和A2a腺苷受体的存在及其相互作用。

Presence of both A1 and A2a adenosine receptors in human cells and their interaction.

作者信息

Ahmed A H, Jacobson K A, Kim J, Heppel L A

机构信息

Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853.

出版信息

Biochem Biophys Res Commun. 1995 Mar 17;208(2):871-8. doi: 10.1006/bbrc.1995.1416.

DOI:10.1006/bbrc.1995.1416
PMID:7695645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5553076/
Abstract

We have obtained pharmacological evidence for the expression of both A1- (inhibitory) and A2a- (stimulatory) adenosine receptors in cultured human foreskin fibroblasts and lung fibroblasts. The A1 receptors were sufficiently abundant in foreskin fibroblasts so that binding studies with a radioactively labeled specific ligand confirmed their existence. Both receptors were activated during the stimulation of cAMP accumulation and DNA synthesis by adenosine.

摘要

我们已获得药理学证据，证明在培养的人包皮成纤维细胞和肺成纤维细胞中同时表达了A1（抑制性）和A2a（刺激性）腺苷受体。A1受体在包皮成纤维细胞中含量丰富，因此用放射性标记的特异性配体进行的结合研究证实了它们的存在。在腺苷刺激cAMP积累和DNA合成过程中，两种受体均被激活。

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本文引用的文献

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Stimulation of aged human lung fibroblasts by extracellular ATP via suppression of arachidonate metabolism.细胞外ATP通过抑制花生四烯酸代谢刺激衰老的人肺成纤维细胞。
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Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes.A1选择性腺苷拮抗剂8-环戊基-1,3-二丙基黄嘌呤与大鼠脑膜的结合。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jan;335(1):59-63. doi: 10.1007/BF00165037.
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Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.作为百日咳毒素（胰岛激活蛋白）底物的鸟嘌呤核苷酸结合蛋白对腺苷酸环化酶催化活性的抑制机制。
J Biol Chem. 1986 Apr 15;261(11):5215-21.
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Adenosine receptor-mediated changes in cyclic AMP production and DNA synthesis in cultured arterial smooth muscle cells.
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Biochemistry. 1989 Jan 24;28(2):611-6. doi: 10.1021/bi00428a029.