人细胞中A1和A2a腺苷受体的存在及其相互作用。
Presence of both A1 and A2a adenosine receptors in human cells and their interaction.
作者信息
Ahmed A H, Jacobson K A, Kim J, Heppel L A
机构信息
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853.
出版信息
Biochem Biophys Res Commun. 1995 Mar 17;208(2):871-8. doi: 10.1006/bbrc.1995.1416.
Abstract
We have obtained pharmacological evidence for the expression of both A1- (inhibitory) and A2a- (stimulatory) adenosine receptors in cultured human foreskin fibroblasts and lung fibroblasts. The A1 receptors were sufficiently abundant in foreskin fibroblasts so that binding studies with a radioactively labeled specific ligand confirmed their existence. Both receptors were activated during the stimulation of cAMP accumulation and DNA synthesis by adenosine.
摘要
我们已获得药理学证据，证明在培养的人包皮成纤维细胞和肺成纤维细胞中同时表达了A1（抑制性）和A2a（刺激性）腺苷受体。A1受体在包皮成纤维细胞中含量丰富，因此用放射性标记的特异性配体进行的结合研究证实了它们的存在。在腺苷刺激cAMP积累和DNA合成过程中，两种受体均被激活。
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本文引用的文献
1
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J Biol Chem. 1993 May 25;268(15):10789-95.
2
3
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.β-肾上腺素能受体激酶的功能活性靶向结构域：Gβγ介导的II型腺苷酸环化酶刺激的抑制剂
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3637-41. doi: 10.1073/pnas.91.9.3637.
4
Adenosine receptor activation in quiescent Swiss 3T3 cells. Enhancement of cAMP levels, DNA synthesis and cell division.静止的瑞士3T3细胞中腺苷受体的激活。环磷酸腺苷（cAMP）水平、DNA合成及细胞分裂的增强。
Exp Cell Res. 1982 May;139(1):71-8. doi: 10.1016/0014-4827(82)90319-6.
5
Stabilization of interferon messenger RNA activity by treatment of cells with metabolic inhibitors and lowering of the incubation temperature.通过用代谢抑制剂处理细胞并降低孵育温度来稳定干扰素信使核糖核酸的活性。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3909-13. doi: 10.1073/pnas.70.12.3909.
6
Purine nucleotides stimulate DNA synthesis in kidney epithelial cells in culture.嘌呤核苷酸可刺激培养的肾上皮细胞中的DNA合成。
Am J Physiol. 1985 Dec;249(6 Pt 2):F967-72. doi: 10.1152/ajprenal.1985.249.6.F967.
7
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8
9
Adenosine receptor-mediated changes in cyclic AMP production and DNA synthesis in cultured arterial smooth muscle cells.
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