Galeano Mariarosaria, Pallio Giovanni, Irrera Natasha, Mannino Federica, Bitto Alessandra, Altavilla Domenica, Vaccaro Mario, Squadrito Giovanni, Arcoraci Vincenzo, Colonna Michele Rosario, Lauro Rita, Squadrito Francesco
Department of Human Pathology and Evolutive Age "Gaetano Barresi", University of Messina, Via C. Valeria, 98125 Messina, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.
Pharmaceuticals (Basel). 2021 Oct 29;14(11):1103. doi: 10.3390/ph14111103.
The normal wound healing process is characterized by a complex, highly integrated cascade of events, requiring the interactions of many cell types, including inflammatory cells, fibroblasts, keratinocytes and endothelial cells, as well as the involvement of growth factors and enzymes. However, several diseases such as diabetes, thermal injury and ischemia could lead to an impaired wound healing process characterized by wound hypoxia, high levels of oxygen radicals, reduced angiogenesis, decreased collagen synthesis and organization. Polydeoxyribonucleotide (PDRN) has been used to improve wound healing through local and systemic administration thanks to its ability to promote cell migration and growth, angiogenesis, and to reduce inflammation on impaired wound healing models in vitro, in vivo and clinical studies. In light of all these observations, the aim of this review is to provide a full overview of PDRN applications on skin regeneration. We reviewed papers published in the last 25 years on PubMed, inserting "polydeoxyribonucleotide and wound healing" as the main search term. All data obtained proved the ability of PDRN in promoting physiological tissue repair through adenosine A receptor activation and salvage pathway suggesting that PDRN has proven encouraging results in terms of healing time, wound regeneration and absence of side effects.
正常的伤口愈合过程具有一系列复杂且高度整合的事件，需要多种细胞类型的相互作用，包括炎症细胞、成纤维细胞、角质形成细胞和内皮细胞，同时还涉及生长因子和酶。然而，诸如糖尿病、热损伤和缺血等几种疾病可导致伤口愈合过程受损，其特征为伤口缺氧、氧自由基水平升高、血管生成减少、胶原蛋白合成及排列减少。聚脱氧核糖核苷酸（PDRN）因其能够促进细胞迁移和生长、血管生成，并在体外、体内及临床研究中对受损伤口愈合模型减轻炎症，已被用于通过局部和全身给药来改善伤口愈合。鉴于所有这些观察结果，本综述的目的是全面概述PDRN在皮肤再生方面的应用。我们检索了过去25年在PubMed上发表的论文，将“聚脱氧核糖核苷酸与伤口愈合”作为主要检索词。所有获得的数据证明，PDRN能够通过腺苷A受体激活和补救途径促进生理性组织修复，这表明PDRN在愈合时间、伤口再生及无副作用方面已取得令人鼓舞的结果。
