Meretoja O A, Taivainen T, Wirtavuori K, Olkkola K T
Department of Anaesthesiology, Children's Hospital University of Helsinki, Finland.
Br J Anaesth. 1994 Oct;73(4):490-3. doi: 10.1093/bja/73.4.490.
A computerized infusion system was used to determine mivacurium infusion requirements to maintain 95% and 50% neuromuscular block in 15 infants less than 1 yr of age. Neuromuscular block was measured by adductor pollicis EMG and anaesthesia maintained with 66% nitrous oxide in oxygen and alfentanil 50-100 micrograms kg-1 h-1. Neuromuscular block was produced by repeated bolus doses of mivacurium 0.1 mg kg-1; subsequently the target neuromuscular block was maintained by a closed loop infusion. Dose potency of mivacurium was similar to that previously published in children with a similar anaesthetic technique. Mean mivacurium requirement for 95% neuromuscular block was 820 (SD 300) micrograms kg-1 h-1, which represented an hourly requirement of 6.6 (1.5) individual ED95 doses. Infusion requirement for 50% neuromuscular block was 320 (150) micrograms kg-1 h-1. These infusion rates were similar to those in children. No side effects of mivacurium were noticed.
使用计算机化输注系统来确定维持15名1岁以下婴儿95%和50%神经肌肉阻滞所需的米库氯铵输注量。通过拇内收肌肌电图测量神经肌肉阻滞，并使用66%氧化亚氮和50 - 100微克/千克/小时的阿芬太尼维持麻醉。通过重复推注0.1毫克/千克的米库氯铵产生神经肌肉阻滞；随后通过闭环输注维持目标神经肌肉阻滞。米库氯铵的剂量效能与先前采用类似麻醉技术的儿童研究结果相似。维持95%神经肌肉阻滞时米库氯铵的平均需求量为820（标准差300）微克/千克/小时，相当于每小时需要6.6（1.5）个ED95个体剂量。维持50%神经肌肉阻滞时的输注需求量为320（150）微克/千克/小时。这些输注速率与儿童相似。未观察到米库氯铵的副作用。
