Armstrong J C, Asfaha W, Palmer T T
Am J Trop Med Hyg. 1976 Jan;25(1):5-9. doi: 10.4269/ajtmh.1976.25.5.
The in vivo response of Plasmodium falciparum to the WHO single test dose (10 mg/kg body weight) of chloroquine base was examined in Ethiopia at four localities where malaria was meso- or hyperendemic. Parasitemias cleared by the 3rd day after chloroquine administration in all of the 150 test subjects. No recrudescences were detected during the 6-day or 11-day follow-up periods. The value of the in vivo test was severely limited by the inability to quarantine subjects and follow them for the 28-day period recommended by the World Health Organization.
在埃塞俄比亚疟疾中度或高度流行的四个地区，对恶性疟原虫针对世界卫生组织单剂量测试剂量（10毫克/千克体重）氯喹碱的体内反应进行了研究。在所有150名受试对象中，给药后第3天寄生虫血症清除。在6天或11天的随访期内未检测到复发。由于无法对受试对象进行检疫并按照世界卫生组织建议的28天期限进行跟踪，体内测试的价值受到严重限制。
