Balldin J, Berggren U, Lindstedt G, Oreland L
Department of Clinical Neuroscience, University of Göteborg, Sweden.
Alcohol Alcohol. 1994 Nov;29(6):659-61.
Platelet monoamine oxidase (MAO) activity, proposed to be a marker for central 5-hydroxytryptamine (5-HT) capacity, was investigated in 14 severely alcohol-dependent subjects with reduced dopamine (DA) D2 receptor function, as assessed by the growth hormone responses to apomorphine. Twelve healthy men were used as controls. Platelet MAO activity in the alcohol-dependent subjects was not different from that in controls. The finding from this preliminary study suggests that severely alcohol-dependent subjects with reduced DA D2 receptor function have normal 5-HT capacity.
血小板单胺氧化酶（MAO）活性被认为是中枢5-羟色胺（5-HT）能力的一个标志物，本研究对14名多巴胺（DA）D2受体功能降低的严重酒精依赖者进行了调查，通过对阿扑吗啡的生长激素反应来评估其DA D2受体功能。选取12名健康男性作为对照。酒精依赖者的血小板MAO活性与对照组无差异。这项初步研究的结果表明，DA D2受体功能降低的严重酒精依赖者具有正常的5-HT能力。
