Wiberg A, Gottfries C G, Oreland L
Med Biol. 1977 Jun;55(3):181-6.
Platelet monoamine oxidase (MAO) activity was found to be significantly reduced in human alcoholics as compared to matched controls. A probable transitory increase in activity was observed during the abstinence phase. The low platelet MAO activity was not due to iron deficiency or to the presence of acetaldehyde. Since we have previously found a lowered MAO activity in the brains of suicide victims, especially in those with a previous history of alcohol abuse, we suggest that low platelet MAO activity reflects a primarily "weak" monoaminergic system in the CNS which causes an increased vulnerability to alcohol abuse and suicidal behaviour.
与配对的对照组相比，发现人类酗酒者的血小板单胺氧化酶（MAO）活性显著降低。在戒酒阶段观察到活性可能有短暂升高。血小板MAO活性低并非由于缺铁或乙醛的存在。由于我们之前在自杀受害者的大脑中发现MAO活性降低，尤其是那些有酗酒史的人，我们认为血小板MAO活性低主要反映了中枢神经系统中“薄弱”的单胺能系统，这导致对酒精滥用和自杀行为的易感性增加。
