List S, Gluud C
Medical Department, Bispebjerg Hospital, Copenhagen, Denmark.
Alcohol Alcohol. 1994 Nov;29(6):757-64.
In the search for genetic factors influencing susceptibility to the development of alcoholism and alcoholic liver disease, 28 studies have been published analysing the distribution of human leucocyte antigens (HLA) in alcoholics compared to healthy controls. A number of HLA-phenotypes has been suspected of being associated with both alcoholism and alcoholic liver disease. In the present study a meta-analysis is carried out on the data from these studies, subdivided according to race and degree of liver injury. The conclusion is that none of the HLA-phenotypes so far investigated in Caucasians can be shown to be significantly more common in any of the studied patient categories than in controls, whereas the results of Japanese studies are less clear. The limitations of the data material and the design of the studies are discussed, as well as the strength and limitations of the method of meta-analysis.
在寻找影响酒精中毒和酒精性肝病易感性的遗传因素的过程中，已有28项研究发表，分析了酗酒者与健康对照者相比人类白细胞抗原（HLA）的分布情况。一些HLA表型被怀疑与酒精中毒和酒精性肝病均有关联。在本研究中，对这些研究的数据进行了荟萃分析，并根据种族和肝损伤程度进行了细分。结论是，到目前为止，在白种人中研究的任何HLA表型，在任何研究的患者类别中都没有显示出比对照组显著更常见，而日本研究的结果则不太明确。讨论了数据材料和研究设计的局限性，以及荟萃分析方法的优势和局限性。
