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一份病例报告提示IgA肾病和过敏性紫癜存在共同的发病机制。

A case report suggesting a common pathogenesis for IgA nephropathy and Henoch-Schönlein purpura.

作者信息

Kaneko K, Suzuki Y, Kiya K, Fukuda Y, Yabuta K

机构信息

Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Pediatr Nephrol. 1994 Dec;8(6):750-1. doi: 10.1007/BF00869110.

DOI:10.1007/BF00869110
PMID:7696118
Abstract

A 7-year-old boy who had been followed for asymptomatic haematuria and elevated serum IgA levels developed Henoch-Schönlein purpura (HSP) after a streptococcal infection of the tonsils. Findings on renal biopsy were compatible with mild IgA nephropathy (IgAN); tonsillectomy was also performed as he had chronic tonsillitis. This case suggests that there is a common pathogenesis for IgAN and HSP, at least in some patients.

摘要

一名7岁男孩因无症状血尿和血清IgA水平升高而接受随访,在扁桃体链球菌感染后发生了过敏性紫癜(HSP)。肾活检结果与轻度IgA肾病(IgAN)相符;由于他患有慢性扁桃体炎,所以也进行了扁桃体切除术。该病例表明,至少在某些患者中,IgAN和HSP存在共同的发病机制。

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引用本文的文献

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Evolution of IgA nephropathy into anaphylactoid purpura in six cases--further evidence that IgA nephropathy and Henoch-Schonlein purpura nephritis share common pathogenesis.6例IgA肾病演变为过敏性紫癜——IgA肾病与过敏性紫癜性肾炎具有共同发病机制的进一步证据
Pediatr Nephrol. 2016 May;31(5):779-85. doi: 10.1007/s00467-015-3290-4. Epub 2015 Dec 17.
2
Three cases of Henoch-Schönlein purpura preceded by IgA nephropathy.3例IgA肾病先于过敏性紫癜发生。
Pediatr Nephrol. 1995 Oct;9(5):674. doi: 10.1007/BF00860974.
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IgA nephropathy--Henoch-Schönlein purpura--common pathogenesis.

本文引用的文献

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2
Pathogenesis of idiopathic IgA nephropathy.特发性IgA肾病的发病机制。
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Immunoglobulin A1 in IgA nephropathy.IgA肾病中的免疫球蛋白A1
IgA肾病——过敏性紫癜——共同发病机制。
Pediatr Nephrol. 1995 Oct;9(5):674. doi: 10.1007/BF00860973.
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7
Henoch-Schönlein syndrome and IgA nephropathy: a case report suggesting a common pathogenesis.过敏性紫癜和IgA肾病:一例提示共同发病机制的病例报告。
Pediatr Nephrol. 1988 Oct;2(4):389-92. doi: 10.1007/BF00853426.
8
Tonsillar distribution of IgA, IgG immunocytes and IgA subclasses in IgA nephropathy.IgA肾病中扁桃体IgA、IgG免疫细胞及IgA亚类的分布
Contrib Nephrol. 1988;67:107-10. doi: 10.1159/000415384.
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Is Henoch-Schönlein purpura the systemic form of IgA nephropathy?
Am J Kidney Dis. 1988 Nov;12(5):373-7. doi: 10.1016/s0272-6386(88)80028-3.
10
Berger disease: Henoch-Schönlein syndrome without the rash.伯杰氏病:无皮疹的过敏性紫癜。
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