Pontieri F E, Colangelo V, La Riccia M, Pozzilli C, Passarelli F, Orzi F
Dipartimento di Scienze Neurologiche, Università degli Studi La Sapienza, Roma, Italy.
Neuroreport. 1994 Dec 20;5(18):2561-4. doi: 10.1097/00001756-199412000-00039.
The nucleus accumbens (NAc) is a heterogeneous area, divided into a 'shell' and a 'core' on the basis of morphological and histochemical criteria. Moreover, the two portions have different anatomical connections. In order to test whether the two portions of NAc are functionally distinct, we measured local cerebral glucose utilization in rats administered intravenously with cocaine (1 mg kg-1) or amphetamine (0.5 mg kg-1). The results of the study show that, at these dosages, both drugs increase glucose utilization in the shell, but not in the core of NAc. This differential effect might reflect functional differences between the two portions of NAc, probably relevant to the abuse liability of psychostimulants.
伏隔核（NAc）是一个异质性区域，根据形态学和组织化学标准可分为“壳”和“核”两部分。此外，这两部分具有不同的解剖学连接。为了测试NAc的这两部分在功能上是否不同，我们测量了静脉注射可卡因（1毫克/千克）或苯丙胺（0.5毫克/千克）的大鼠的局部脑葡萄糖利用率。研究结果表明，在这些剂量下，两种药物均增加了NAc壳部的葡萄糖利用率，但未增加核部的葡萄糖利用率。这种差异效应可能反映了NAc两部分之间的功能差异，这可能与精神兴奋剂的滥用倾向有关。
