Orzi F, Passarelli F, La Riccia M, Di Grezia R, Pontieri F E
Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma, Italy.
Eur J Pharmacol. 1996 Apr 29;302(1-3):49-51. doi: 10.1016/0014-2999(96)00128-8.
The [14C]2-deoxyglucose method was applied to measure the effects of the acute intravenous administration of morphine sulphate (0.2-0.4 mg/kg) on cerebral glucose utilization in rats. Morphine produced dose-dependent increases of glucose metabolism in the shell of the nucleus accumbens, without affecting functional activity in any other brain area. These results provide further evidence for the preferential effects of intravenously abused substances in the shell of the nucleus accumbens.
采用[14C]2-脱氧葡萄糖法来测定硫酸吗啡（0.2 - 0.4毫克/千克）急性静脉注射对大鼠脑葡萄糖利用的影响。吗啡使伏隔核壳部的葡萄糖代谢呈剂量依赖性增加，而不影响其他任何脑区的功能活性。这些结果为静脉滥用物质对伏隔核壳部的优先作用提供了进一步的证据。
