Lerner-Natoli M, de Bock F, Bockaert J, Rondouin G
CNRS UPR 9008, INSERM U 249, Laboratoire de Médecine Expérimentale, Montpellie, France.
Neuroreport. 1994 Dec 20;5(18):2633-7. doi: 10.1097/00001756-199412000-00057.
Using NADPH-diaphorase (NADPH-d) histochemistry, the expression of nitric oxide synthase (NOS) was studied in the rat brain 1 week after kainate-induced status epilepticus. Major changes were observed in the hippocampi of epileptic animals, especially a loss of NADPH-d positive fibres in the periphery of degenerative pyramidal cells, the survival of NOS-containing interneurones in the dentate hilus, a different pattern of NADPH-d staining in lesioned areas, probably corresponding to the expression of inducible NOS by glial cells and an increased staining of the vasculature. These different sources of NO may exert different functions in the epileptic focus.
运用还原型辅酶Ⅱ黄递酶（NADPH-d）组织化学方法，研究了在海藻酸诱发癫痫持续状态1周后的大鼠脑中一氧化氮合酶（NOS）的表达情况。在癫痫动物的海马体中观察到了主要变化，尤其是在变性锥体细胞周边的NADPH-d阳性纤维缺失、齿状回门中含NOS的中间神经元存活、损伤区域NADPH-d染色模式不同，这可能对应着胶质细胞诱导型NOS的表达以及血管染色增强。这些不同来源的一氧化氮可能在癫痫病灶中发挥不同功能。
